Analysis Type: PANTHER Overrepresentation Test (Released 20181113) Annotation Version and Release Date: GO Ontology database Released 2018-10-08 Analyzed List: T13C1_DOWN_0.1.genes (Homo sapiens) There are duplicate IDs in the file. The unique set of IDs will be used. Reference List: background.genes (Homo sapiens) There are duplicate IDs in the file. The unique set of IDs will be used. Test Type: FISHER Correction: FDR GO biological process complete background.genes - REFLIST (15398) T13C1_DOWN_0.1.genes (1690) T13C1_DOWN_0.1.genes (expected) T13C1_DOWN_0.1.genes (over/under) T13C1_DOWN_0.1.genes (fold Enrichment) T13C1_DOWN_0.1.genes (raw P-value) T13C1_DOWN_0.1.genes (FDR) secondary alcohol biosynthetic process (GO:1902653) 37 22 4.06 + 5.42 1.66E-08 1.19E-05 sterol biosynthetic process (GO:0016126) 41 24 4.50 + 5.33 4.70E-09 4.70E-06 cholesterol biosynthetic process (GO:0006695) 36 21 3.95 + 5.31 4.49E-08 2.59E-05 DNA replication checkpoint (GO:0000076) 16 9 1.76 + 5.13 4.16E-04 4.13E-02 regulation of cholesterol biosynthetic process (GO:0045540) 42 21 4.61 + 4.56 3.24E-07 1.35E-04 regulation of sterol biosynthetic process (GO:0106118) 42 21 4.61 + 4.56 3.24E-07 1.31E-04 fatty-acyl-CoA biosynthetic process (GO:0046949) 26 12 2.85 + 4.21 1.97E-04 2.29E-02 regulation of cholesterol metabolic process (GO:0090181) 53 23 5.82 + 3.95 6.45E-07 2.54E-04 nuclear DNA replication (GO:0033260) 36 15 3.95 + 3.80 8.12E-05 1.22E-02 cell cycle DNA replication (GO:0044786) 37 15 4.06 + 3.69 1.04E-04 1.44E-02 secondary alcohol metabolic process (GO:1902652) 96 38 10.54 + 3.61 1.28E-09 2.14E-06 cholesterol metabolic process (GO:0008203) 92 36 10.10 + 3.57 4.43E-09 4.75E-06 sterol metabolic process (GO:0016125) 105 41 11.52 + 3.56 4.01E-10 1.20E-06 fatty-acyl-CoA metabolic process (GO:0035337) 34 13 3.73 + 3.48 4.66E-04 4.60E-02 regulation of alcohol biosynthetic process (GO:1902930) 65 24 7.13 + 3.36 3.67E-06 1.02E-03 alcohol biosynthetic process (GO:0046165) 81 28 8.89 + 3.15 1.69E-06 5.90E-04 steroid biosynthetic process (GO:0006694) 96 33 10.54 + 3.13 2.30E-07 1.04E-04 regulation of steroid biosynthetic process (GO:0050810) 73 25 8.01 + 3.12 6.84E-06 1.55E-03 DNA-dependent DNA replication (GO:0006261) 115 37 12.62 + 2.93 1.73E-07 8.36E-05 regulation of steroid metabolic process (GO:0019218) 92 29 10.10 + 2.87 8.22E-06 1.76E-03 fatty acid biosynthetic process (GO:0006633) 90 26 9.88 + 2.63 5.79E-05 9.14E-03 DNA replication (GO:0006260) 202 56 22.17 + 2.53 1.93E-08 1.31E-05 alcohol metabolic process (GO:0006066) 242 67 26.56 + 2.52 5.15E-10 1.29E-06 coenzyme biosynthetic process (GO:0009108) 156 43 17.12 + 2.51 8.82E-07 3.30E-04 regulation of lipid biosynthetic process (GO:0046890) 151 41 16.57 + 2.47 2.07E-06 6.60E-04 steroid metabolic process (GO:0008202) 189 51 20.74 + 2.46 1.48E-07 7.64E-05 isoprenoid metabolic process (GO:0006720) 90 24 9.88 + 2.43 3.68E-04 3.76E-02 purine ribonucleotide biosynthetic process (GO:0009152) 166 44 18.22 + 2.42 1.83E-06 6.10E-04 purine nucleotide biosynthetic process (GO:0006164) 174 46 19.10 + 2.41 9.82E-07 3.59E-04 G1/S transition of mitotic cell cycle (GO:0000082) 111 29 12.18 + 2.38 1.51E-04 1.87E-02 organic hydroxy compound biosynthetic process (GO:1901617) 135 35 14.82 + 2.36 2.45E-05 4.18E-03 cell cycle G1/S phase transition (GO:0044843) 112 29 12.29 + 2.36 1.59E-04 1.96E-02 purine-containing compound biosynthetic process (GO:0072522) 186 48 20.41 + 2.35 1.23E-06 4.39E-04 ribonucleotide biosynthetic process (GO:0009260) 180 46 19.76 + 2.33 2.56E-06 8.00E-04 ribose phosphate biosynthetic process (GO:0046390) 185 47 20.30 + 2.31 1.98E-06 6.46E-04 purine nucleoside bisphosphate metabolic process (GO:0034032) 115 28 12.62 + 2.22 3.70E-04 3.75E-02 ribonucleoside bisphosphate metabolic process (GO:0033875) 115 28 12.62 + 2.22 3.70E-04 3.72E-02 nucleoside bisphosphate metabolic process (GO:0033865) 115 28 12.62 + 2.22 3.70E-04 3.70E-02 organic hydroxy compound metabolic process (GO:1901615) 345 83 37.87 + 2.19 1.84E-09 2.51E-06 cell junction assembly (GO:0034329) 142 34 15.59 + 2.18 1.76E-04 2.08E-02 cofactor biosynthetic process (GO:0051188) 206 49 22.61 + 2.17 6.17E-06 1.47E-03 coenzyme metabolic process (GO:0006732) 273 64 29.96 + 2.14 2.75E-07 1.18E-04 DNA integrity checkpoint (GO:0031570) 144 33 15.80 + 2.09 3.28E-04 3.49E-02 monocarboxylic acid biosynthetic process (GO:0072330) 175 40 19.21 + 2.08 7.75E-05 1.19E-02 lipid biosynthetic process (GO:0008610) 498 112 54.66 + 2.05 7.49E-11 3.74E-07 nucleotide biosynthetic process (GO:0009165) 255 57 27.99 + 2.04 5.07E-06 1.31E-03 organophosphate biosynthetic process (GO:0090407) 520 115 57.07 + 2.01 1.09E-10 4.08E-07 nucleoside phosphate biosynthetic process (GO:1901293) 258 57 28.32 + 2.01 6.07E-06 1.47E-03 cell junction organization (GO:0034330) 180 39 19.76 + 1.97 3.42E-04 3.59E-02 angiogenesis (GO:0001525) 270 58 29.63 + 1.96 1.35E-05 2.67E-03 small molecule biosynthetic process (GO:0044283) 490 103 53.78 + 1.92 1.02E-08 8.08E-06 developmental growth (GO:0048589) 295 62 32.38 + 1.91 9.58E-06 1.99E-03 phospholipid biosynthetic process (GO:0008654) 240 50 26.34 + 1.90 9.28E-05 1.36E-02 growth (GO:0040007) 299 62 32.82 + 1.89 1.55E-05 2.90E-03 regulation of lipid metabolic process (GO:0019216) 323 65 35.45 + 1.83 2.12E-05 3.75E-03 blood vessel morphogenesis (GO:0048514) 342 68 37.54 + 1.81 2.37E-05 4.08E-03 phospholipid metabolic process (GO:0006644) 369 73 40.50 + 1.80 1.11E-05 2.24E-03 carboxylic acid biosynthetic process (GO:0046394) 269 53 29.52 + 1.80 2.10E-04 2.36E-02 organic acid biosynthetic process (GO:0016053) 270 53 29.63 + 1.79 2.18E-04 2.44E-02 blood vessel development (GO:0001568) 413 81 45.33 + 1.79 5.30E-06 1.35E-03 cell cycle phase transition (GO:0044770) 255 50 27.99 + 1.79 3.18E-04 3.43E-02 extracellular structure organization (GO:0043062) 287 56 31.50 + 1.78 1.62E-04 1.98E-02 positive regulation of cell adhesion (GO:0045785) 314 61 34.46 + 1.77 1.04E-04 1.47E-02 lipid metabolic process (GO:0006629) 1003 190 110.08 + 1.73 1.58E-11 1.19E-07 purine nucleotide metabolic process (GO:0006163) 392 74 43.02 + 1.72 3.85E-05 6.20E-03 vasculature development (GO:0001944) 435 82 47.74 + 1.72 1.73E-05 3.21E-03 gland development (GO:0048732) 315 59 34.57 + 1.71 3.01E-04 3.27E-02 cardiovascular system development (GO:0072358) 444 83 48.73 + 1.70 2.08E-05 3.71E-03 purine ribonucleotide metabolic process (GO:0009150) 375 70 41.16 + 1.70 9.97E-05 1.44E-02 ribonucleotide metabolic process (GO:0009259) 391 72 42.91 + 1.68 1.00E-04 1.43E-02 chemotaxis (GO:0006935) 386 71 42.37 + 1.68 1.24E-04 1.65E-02 organophosphate metabolic process (GO:0019637) 914 168 100.32 + 1.67 1.61E-09 2.41E-06 tube morphogenesis (GO:0035239) 534 98 58.61 + 1.67 6.46E-06 1.51E-03 regulation of cell adhesion (GO:0030155) 535 98 58.72 + 1.67 6.62E-06 1.53E-03 taxis (GO:0042330) 388 71 42.58 + 1.67 1.31E-04 1.71E-02 purine-containing compound metabolic process (GO:0072521) 422 77 46.32 + 1.66 7.06E-05 1.09E-02 cellular lipid metabolic process (GO:0044255) 824 150 90.44 + 1.66 2.66E-08 1.59E-05 ribose phosphate metabolic process (GO:0019693) 408 74 44.78 + 1.65 1.35E-04 1.73E-02 monocarboxylic acid metabolic process (GO:0032787) 404 73 44.34 + 1.65 1.71E-04 2.05E-02 cofactor metabolic process (GO:0051186) 427 77 46.87 + 1.64 1.04E-04 1.45E-02 carbohydrate derivative biosynthetic process (GO:1901137) 564 101 61.90 + 1.63 1.10E-05 2.26E-03 cell-cell adhesion (GO:0098609) 387 69 42.47 + 1.62 3.25E-04 3.48E-02 tube development (GO:0035295) 675 118 74.08 + 1.59 5.84E-06 1.43E-03 nucleobase-containing small molecule metabolic process (GO:0055086) 601 105 65.96 + 1.59 1.94E-05 3.51E-03 nucleotide metabolic process (GO:0009117) 518 90 56.85 + 1.58 9.86E-05 1.43E-02 biological adhesion (GO:0022610) 732 127 80.34 + 1.58 3.22E-06 9.47E-04 cell adhesion (GO:0007155) 727 126 79.79 + 1.58 3.96E-06 1.06E-03 circulatory system development (GO:0072359) 710 123 77.93 + 1.58 5.46E-06 1.36E-03 nucleoside phosphate metabolic process (GO:0006753) 524 90 57.51 + 1.56 1.42E-04 1.77E-02 response to cytokine (GO:0034097) 788 135 86.49 + 1.56 2.99E-06 8.97E-04 cellular response to cytokine stimulus (GO:0071345) 712 120 78.15 + 1.54 2.17E-05 3.78E-03 regulation of cell migration (GO:0030334) 683 115 74.96 + 1.53 3.35E-05 5.46E-03 anatomical structure formation involved in morphogenesis (GO:0048646) 691 114 75.84 + 1.50 7.91E-05 1.20E-02 small molecule metabolic process (GO:0044281) 1529 250 167.81 + 1.49 2.90E-09 3.34E-06 cell migration (GO:0016477) 656 107 72.00 + 1.49 1.88E-04 2.20E-02 regulation of cell motility (GO:2000145) 729 118 80.01 + 1.47 1.18E-04 1.60E-02 carboxylic acid metabolic process (GO:0019752) 736 119 80.78 + 1.47 1.26E-04 1.65E-02 response to abiotic stimulus (GO:0009628) 924 149 101.41 + 1.47 1.41E-05 2.75E-03 DNA metabolic process (GO:0006259) 728 116 79.90 + 1.45 2.35E-04 2.59E-02 animal organ morphogenesis (GO:0009887) 697 111 76.50 + 1.45 3.51E-04 3.61E-02 locomotion (GO:0040011) 931 148 102.18 + 1.45 3.01E-05 4.97E-03 epithelium development (GO:0060429) 718 114 78.80 + 1.45 3.38E-04 3.57E-02 regulation of cellular component movement (GO:0051270) 797 126 87.47 + 1.44 1.74E-04 2.08E-02 tissue development (GO:0009888) 1205 190 132.25 + 1.44 3.35E-06 9.66E-04 oxoacid metabolic process (GO:0043436) 817 128 89.67 + 1.43 2.07E-04 2.35E-02 positive regulation of multicellular organismal process (GO:0051240) 1311 203 143.89 + 1.41 3.99E-06 1.05E-03 organic acid metabolic process (GO:0006082) 827 128 90.77 + 1.41 3.43E-04 3.57E-02 response to external stimulus (GO:0009605) 1434 221 157.39 + 1.40 1.77E-06 6.05E-04 carbohydrate derivative metabolic process (GO:1901135) 967 149 106.13 + 1.40 1.19E-04 1.61E-02 negative regulation of multicellular organismal process (GO:0051241) 929 143 101.96 + 1.40 1.70E-04 2.05E-02 anatomical structure morphogenesis (GO:0009653) 1633 249 179.23 + 1.39 6.92E-07 2.66E-04 organic cyclic compound biosynthetic process (GO:1901362) 1194 181 131.05 + 1.38 4.88E-05 7.78E-03 movement of cell or subcellular component (GO:0006928) 1122 170 123.14 + 1.38 8.31E-05 1.23E-02 response to oxygen-containing compound (GO:1901700) 1161 172 127.42 + 1.35 2.27E-04 2.52E-02 organic substance biosynthetic process (GO:1901576) 2535 372 278.23 + 1.34 2.53E-08 1.65E-05 homeostatic process (GO:0042592) 1241 182 136.21 + 1.34 2.03E-04 2.33E-02 animal organ development (GO:0048513) 2300 337 252.44 + 1.33 1.74E-07 8.14E-05 biosynthetic process (GO:0009058) 2579 377 283.06 + 1.33 2.59E-08 1.62E-05 regulation of multicellular organismal process (GO:0051239) 2364 344 259.46 + 1.33 2.36E-07 1.04E-04 cellular response to organic substance (GO:0071310) 1764 256 193.61 + 1.32 1.48E-05 2.80E-03 phosphorus metabolic process (GO:0006793) 1907 276 209.30 + 1.32 8.15E-06 1.77E-03 regulation of biological quality (GO:0065008) 3127 449 343.20 + 1.31 5.24E-09 4.91E-06 regulation of developmental process (GO:0050793) 2022 290 221.92 + 1.31 8.01E-06 1.77E-03 regulation of cell differentiation (GO:0045595) 1391 199 152.67 + 1.30 3.47E-04 3.59E-02 response to organic substance (GO:0010033) 2252 322 247.17 + 1.30 2.60E-06 7.97E-04 phosphate-containing compound metabolic process (GO:0006796) 1880 268 206.34 + 1.30 2.92E-05 4.92E-03 regulation of multicellular organismal development (GO:2000026) 1578 224 173.19 + 1.29 2.01E-04 2.32E-02 system development (GO:0048731) 3318 470 364.17 + 1.29 9.07E-09 7.56E-06 response to chemical (GO:0042221) 3040 427 333.65 + 1.28 1.67E-07 8.32E-05 cellular biosynthetic process (GO:0044249) 2461 343 270.11 + 1.27 9.25E-06 1.95E-03 cell differentiation (GO:0030154) 2706 376 297.00 + 1.27 3.52E-06 9.97E-04 cellular developmental process (GO:0048869) 2782 385 305.34 + 1.26 3.79E-06 1.03E-03 cellular response to chemical stimulus (GO:0070887) 2153 296 236.30 + 1.25 1.21E-04 1.62E-02 regulation of localization (GO:0032879) 2139 294 234.76 + 1.25 1.35E-04 1.74E-02 multicellular organism development (GO:0007275) 3757 516 412.35 + 1.25 5.90E-08 3.27E-05 response to stress (GO:0006950) 2641 362 289.86 + 1.25 1.87E-05 3.41E-03 developmental process (GO:0032502) 4313 588 473.37 + 1.24 8.48E-09 7.48E-06 anatomical structure development (GO:0048856) 4039 548 443.30 + 1.24 8.49E-08 4.55E-05 multicellular organismal process (GO:0032501) 4793 648 526.05 + 1.23 2.68E-09 3.35E-06 organic cyclic compound metabolic process (GO:1901360) 2998 393 329.04 + 1.19 2.80E-04 3.06E-02 response to stimulus (GO:0050896) 5945 773 652.49 + 1.18 1.64E-08 1.23E-05 cellular component organization (GO:0016043) 4719 607 517.93 + 1.17 1.22E-05 2.43E-03 cellular component organization or biogenesis (GO:0071840) 4892 629 536.92 + 1.17 6.91E-06 1.55E-03 cellular response to stimulus (GO:0051716) 4737 608 519.91 + 1.17 1.42E-05 2.72E-03 positive regulation of cellular process (GO:0048522) 4248 545 466.24 + 1.17 6.45E-05 1.01E-02 positive regulation of biological process (GO:0048518) 4741 605 520.35 + 1.16 2.98E-05 4.97E-03 cellular process (GO:0009987) 11157 1359 1224.53 + 1.11 6.18E-13 9.27E-09 biological_process (GO:0008150) 13525 1565 1484.43 + 1.05 1.19E-09 2.23E-06 Unclassified (UNCLASSIFIED) 1873 125 205.57 - .61 1.19E-09 2.55E-06 mRNA splicing, via spliceosome (GO:0000398) 279 11 30.62 - .36 1.41E-04 1.80E-02 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) 279 11 30.62 - .36 1.41E-04 1.78E-02 RNA splicing, via transesterification reactions (GO:0000375) 282 11 30.95 - .36 1.05E-04 1.44E-02