Analysis Type:	PANTHER Overrepresentation Test (Released 20181113)
Annotation Version and Release Date:	GO Ontology database  Released 2018-10-08
Analyzed List:	T12C1_DOWN_0.1.genes (Homo sapiens)	There are duplicate IDs in the file. The unique set of IDs will be used.
Reference List:	background.genes (Homo sapiens)	There are duplicate IDs in the file. The unique set of IDs will be used.
Test Type:	FISHER
Correction:	FDR
GO biological process complete	background.genes - REFLIST (15398)	T12C1_DOWN_0.1.genes (901)	T12C1_DOWN_0.1.genes (expected)	T12C1_DOWN_0.1.genes (over/under)	T12C1_DOWN_0.1.genes (fold Enrichment)	T12C1_DOWN_0.1.genes (raw P-value)	T12C1_DOWN_0.1.genes (FDR)
septum primum development (GO:0003284)	4	4	.23	+	17.09	5.43E-04	2.69E-02
lymphatic endothelial cell differentiation (GO:0060836)	7	5	.41	+	12.21	2.92E-04	1.74E-02
cardiac atrium morphogenesis (GO:0003209)	21	9	1.23	+	7.32	2.31E-05	2.16E-03
positive regulation of cardiac muscle cell proliferation (GO:0060045)	18	7	1.05	+	6.65	3.08E-04	1.81E-02
cardiac atrium development (GO:0003230)	25	9	1.46	+	6.15	6.94E-05	5.62E-03
regulation of cardiac muscle cell proliferation (GO:0060043)	30	10	1.76	+	5.70	4.71E-05	4.06E-03
response to vitamin D (GO:0033280)	21	7	1.23	+	5.70	6.56E-04	3.08E-02
ventricular septum morphogenesis (GO:0060412)	35	10	2.05	+	4.88	1.38E-04	9.93E-03
regulation of cardiac muscle tissue growth (GO:0055021)	46	13	2.69	+	4.83	1.56E-05	1.55E-03
positive regulation of heart growth (GO:0060421)	29	8	1.70	+	4.71	7.78E-04	3.53E-02
heart trabecula morphogenesis (GO:0061384)	29	8	1.70	+	4.71	7.78E-04	3.52E-02
regulation of heart growth (GO:0060420)	51	14	2.98	+	4.69	9.77E-06	1.04E-03
digestive tract morphogenesis (GO:0048546)	30	8	1.76	+	4.56	9.38E-04	4.10E-02
cardiac septum morphogenesis (GO:0060411)	57	15	3.34	+	4.50	7.31E-06	8.11E-04
negative chemotaxis (GO:0050919)	38	10	2.22	+	4.50	2.43E-04	1.53E-02
positive regulation of organ growth (GO:0046622)	38	10	2.22	+	4.50	2.43E-04	1.52E-02
ventricular cardiac muscle tissue morphogenesis (GO:0055010)	35	9	2.05	+	4.39	5.70E-04	2.77E-02
trabecula morphogenesis (GO:0061383)	39	10	2.28	+	4.38	2.90E-04	1.74E-02
regulation of cardiocyte differentiation (GO:1905207)	40	10	2.34	+	4.27	3.45E-04	1.98E-02
ventricular cardiac muscle tissue development (GO:0003229)	40	10	2.34	+	4.27	3.45E-04	1.97E-02
regulation of cardiac muscle tissue development (GO:0055024)	61	15	3.57	+	4.20	1.46E-05	1.46E-03
artery morphogenesis (GO:0048844)	50	12	2.93	+	4.10	1.26E-04	9.36E-03
regulation of sodium ion transmembrane transporter activity (GO:2000649)	42	10	2.46	+	4.07	4.81E-04	2.45E-02
regulation of action potential (GO:0098900)	38	9	2.22	+	4.05	9.45E-04	4.12E-02
cardiac muscle tissue morphogenesis (GO:0055008)	51	12	2.98	+	4.02	1.48E-04	1.05E-02
cardiac ventricle morphogenesis (GO:0003208)	48	11	2.81	+	3.92	3.37E-04	1.94E-02
ventricular septum development (GO:0003281)	58	13	3.39	+	3.83	1.21E-04	9.02E-03
regulation of organ growth (GO:0046620)	76	17	4.45	+	3.82	1.17E-05	1.21E-03
endothelium development (GO:0003158)	81	18	4.74	+	3.80	7.07E-06	7.97E-04
odontogenesis of dentin-containing tooth (GO:0042475)	50	11	2.93	+	3.76	4.56E-04	2.36E-02
cardiac chamber morphogenesis (GO:0003206)	91	20	5.32	+	3.76	2.57E-06	3.35E-04
organ growth (GO:0035265)	64	14	3.74	+	3.74	8.40E-05	6.59E-03
muscle tissue morphogenesis (GO:0060415)	57	12	3.34	+	3.60	3.61E-04	2.03E-02
cellular response to nutrient (GO:0031670)	48	10	2.81	+	3.56	1.18E-03	4.88E-02
cardiac muscle tissue development (GO:0048738)	121	25	7.08	+	3.53	4.08E-07	6.88E-05
cardiac septum development (GO:0003279)	88	18	5.15	+	3.50	1.89E-05	1.82E-03
odontogenesis (GO:0042476)	75	15	4.39	+	3.42	1.14E-04	8.61E-03
endothelial cell differentiation (GO:0045446)	70	14	4.10	+	3.42	1.91E-04	1.28E-02
digestive tract development (GO:0048565)	86	17	5.03	+	3.38	4.65E-05	4.03E-03
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	81	16	4.74	+	3.38	7.77E-05	6.20E-03
regulation of sodium ion transport (GO:0002028)	71	14	4.15	+	3.37	2.18E-04	1.41E-02
artery development (GO:0060840)	71	14	4.15	+	3.37	2.18E-04	1.41E-02
negative regulation of developmental growth (GO:0048640)	92	18	5.38	+	3.34	3.16E-05	2.89E-03
heart process (GO:0003015)	72	14	4.21	+	3.32	2.47E-04	1.54E-02
peripheral nervous system development (GO:0007422)	57	11	3.34	+	3.30	1.17E-03	4.89E-02
digestive system development (GO:0055123)	94	18	5.50	+	3.27	4.05E-05	3.57E-03
muscle organ morphogenesis (GO:0048644)	63	12	3.69	+	3.26	7.89E-04	3.56E-02
kidney epithelium development (GO:0072073)	91	17	5.32	+	3.19	8.60E-05	6.72E-03
heart morphogenesis (GO:0003007)	187	34	10.94	+	3.11	5.56E-08	1.26E-05
cardiac muscle cell differentiation (GO:0055007)	66	12	3.86	+	3.11	1.13E-03	4.76E-02
cardiac ventricle development (GO:0003231)	95	17	5.56	+	3.06	1.36E-04	9.88E-03
neuron migration (GO:0001764)	86	15	5.03	+	2.98	4.22E-04	2.25E-02
nephron development (GO:0072006)	86	15	5.03	+	2.98	4.22E-04	2.24E-02
cardiac chamber development (GO:0003205)	127	22	7.43	+	2.96	2.34E-05	2.18E-03
regulation of muscle tissue development (GO:1901861)	104	18	6.09	+	2.96	1.27E-04	9.40E-03
regulation of striated muscle tissue development (GO:0016202)	104	18	6.09	+	2.96	1.27E-04	9.35E-03
actomyosin structure organization (GO:0031032)	87	15	5.09	+	2.95	4.70E-04	2.43E-02
regulation of muscle organ development (GO:0048634)	105	18	6.14	+	2.93	1.41E-04	1.01E-02
negative regulation of ion transport (GO:0043271)	106	18	6.20	+	2.90	1.57E-04	1.09E-02
morphogenesis of a branching structure (GO:0001763)	124	21	7.26	+	2.89	4.76E-05	4.06E-03
kidney development (GO:0001822)	201	32	11.76	+	2.72	1.81E-06	2.47E-04
regulation of smooth muscle cell proliferation (GO:0048660)	107	17	6.26	+	2.72	4.71E-04	2.42E-02
positive regulation of developmental growth (GO:0048639)	139	22	8.13	+	2.70	7.78E-05	6.17E-03
renal system development (GO:0072001)	214	33	12.52	+	2.64	3.04E-06	3.90E-04
striated muscle cell differentiation (GO:0051146)	150	23	8.78	+	2.62	1.34E-04	9.72E-03
male gonad development (GO:0008584)	111	17	6.50	+	2.62	6.82E-04	3.18E-02
cell fate commitment (GO:0045165)	144	22	8.43	+	2.61	1.99E-04	1.32E-02
regulation of morphogenesis of an epithelium (GO:1905330)	105	16	6.14	+	2.60	1.02E-03	4.36E-02
regulation of muscle system process (GO:0090257)	171	26	10.01	+	2.60	4.60E-05	4.03E-03
regulation of blood pressure (GO:0008217)	125	19	7.31	+	2.60	3.69E-04	2.05E-02
urogenital system development (GO:0001655)	237	36	13.87	+	2.60	1.28E-06	1.88E-04
development of primary male sexual characteristics (GO:0046546)	112	17	6.55	+	2.59	7.46E-04	3.42E-02
morphogenesis of a branching epithelium (GO:0061138)	119	18	6.96	+	2.59	5.48E-04	2.70E-02
mesenchymal cell differentiation (GO:0048762)	113	17	6.61	+	2.57	8.15E-04	3.65E-02
regulation of animal organ morphogenesis (GO:2000027)	160	24	9.36	+	2.56	1.07E-04	8.07E-03
positive regulation of epithelial cell proliferation (GO:0050679)	140	21	8.19	+	2.56	3.19E-04	1.85E-02
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	128	19	7.49	+	2.54	7.05E-04	3.26E-02
striated muscle tissue development (GO:0014706)	217	32	12.70	+	2.52	8.18E-06	8.89E-04
muscle tissue development (GO:0060537)	225	33	13.17	+	2.51	6.43E-06	7.36E-04
positive regulation of stress-activated MAPK cascade (GO:0032874)	130	19	7.61	+	2.50	7.69E-04	3.50E-02
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304)	131	19	7.67	+	2.48	8.07E-04	3.63E-02
lung development (GO:0030324)	131	19	7.67	+	2.48	8.07E-04	3.62E-02
circulatory system process (GO:0003013)	276	40	16.15	+	2.48	1.10E-06	1.65E-04
regulation of ossification (GO:0030278)	138	20	8.07	+	2.48	5.73E-04	2.77E-02
mesenchyme development (GO:0060485)	152	22	8.89	+	2.47	2.92E-04	1.74E-02
positive regulation of cell migration (GO:0030335)	402	58	23.52	+	2.47	4.52E-09	1.35E-06
positive regulation of epithelial cell migration (GO:0010634)	125	18	7.31	+	2.46	1.20E-03	4.96E-02
regulation of developmental growth (GO:0048638)	271	39	15.86	+	2.46	1.70E-06	2.41E-04
epidermis development (GO:0008544)	188	27	11.00	+	2.45	6.17E-05	5.08E-03
positive regulation of cell motility (GO:2000147)	416	59	24.34	+	2.42	4.78E-09	1.41E-06
respiratory tube development (GO:0030323)	135	19	7.90	+	2.41	1.01E-03	4.32E-02
respiratory system development (GO:0060541)	150	21	8.78	+	2.39	5.55E-04	2.71E-02
epithelial tube morphogenesis (GO:0060562)	237	33	13.87	+	2.38	1.91E-05	1.83E-03
positive regulation of vasculature development (GO:1904018)	151	21	8.84	+	2.38	5.92E-04	2.85E-02
regulation of blood circulation (GO:1903522)	180	25	10.53	+	2.37	2.75E-04	1.67E-02
positive regulation of angiogenesis (GO:0045766)	137	19	8.02	+	2.37	1.13E-03	4.75E-02
muscle cell differentiation (GO:0042692)	188	26	11.00	+	2.36	2.00E-04	1.32E-02
regulation of heart contraction (GO:0008016)	152	21	8.89	+	2.36	6.33E-04	3.00E-02
positive regulation of cellular component movement (GO:0051272)	428	59	25.04	+	2.36	1.36E-08	3.71E-06
blood circulation (GO:0008015)	270	37	15.80	+	2.34	1.09E-05	1.14E-03
regulation of metal ion transport (GO:0010959)	285	39	16.68	+	2.34	5.70E-06	6.73E-04
tube morphogenesis (GO:0035239)	534	73	31.25	+	2.34	2.96E-10	1.35E-07
regulation of cell migration (GO:0030334)	683	93	39.97	+	2.33	1.29E-12	1.14E-09
tissue morphogenesis (GO:0048729)	423	57	24.75	+	2.30	4.31E-08	1.01E-05
regulation of cellular component movement (GO:0051270)	797	107	46.64	+	2.29	3.58E-14	6.72E-11
development of primary sexual characteristics (GO:0045137)	172	23	10.06	+	2.29	6.72E-04	3.15E-02
heart development (GO:0007507)	412	55	24.11	+	2.28	1.48E-07	3.01E-05
MAPK cascade (GO:0000165)	270	36	15.80	+	2.28	1.98E-05	1.89E-03
positive regulation of locomotion (GO:0040017)	443	59	25.92	+	2.28	4.26E-08	1.01E-05
regulation of cell motility (GO:2000145)	729	97	42.66	+	2.27	1.15E-12	1.08E-09
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	188	25	11.00	+	2.27	3.78E-04	2.10E-02
positive regulation of growth (GO:0045927)	211	28	12.35	+	2.27	1.60E-04	1.09E-02
gonad development (GO:0008406)	166	22	9.71	+	2.26	9.79E-04	4.23E-02
regulation of locomotion (GO:0040012)	789	104	46.17	+	2.25	2.65E-13	3.06E-10
regulation of epithelial cell migration (GO:0010632)	190	25	11.12	+	2.25	4.18E-04	2.24E-02
sex differentiation (GO:0007548)	198	26	11.59	+	2.24	3.20E-04	1.85E-02
epithelial cell differentiation (GO:0030855)	384	50	22.47	+	2.23	9.80E-07	1.50E-04
signal transduction by protein phosphorylation (GO:0023014)	292	38	17.09	+	2.22	2.34E-05	2.17E-03
negative regulation of locomotion (GO:0040013)	269	35	15.74	+	2.22	3.69E-05	3.33E-03
regulation of synapse organization (GO:0050807)	177	23	10.36	+	2.22	8.41E-04	3.72E-02
regulation of calcium ion transport (GO:0051924)	185	24	10.83	+	2.22	6.41E-04	3.03E-02
reproductive structure development (GO:0048608)	324	42	18.96	+	2.22	7.25E-06	8.12E-04
tube development (GO:0035295)	675	87	39.50	+	2.20	1.02E-10	5.08E-08
vasculature development (GO:0001944)	435	56	25.45	+	2.20	3.09E-07	5.58E-05
blood vessel morphogenesis (GO:0048514)	342	44	20.01	+	2.20	4.70E-06	5.77E-04
regulation of stress-activated MAPK cascade (GO:0032872)	187	24	10.94	+	2.19	7.14E-04	3.30E-02
blood vessel development (GO:0001568)	413	53	24.17	+	2.19	5.31E-07	8.38E-05
positive regulation of MAPK cascade (GO:0043410)	429	55	25.10	+	2.19	4.43E-07	7.14E-05
reproductive system development (GO:0061458)	328	42	19.19	+	2.19	8.81E-06	9.50E-04
positive regulation of MAP kinase activity (GO:0043406)	211	27	12.35	+	2.19	4.52E-04	2.36E-02
plasma membrane bounded cell projection morphogenesis (GO:0120039)	383	49	22.41	+	2.19	1.71E-06	2.40E-04
cell projection morphogenesis (GO:0048858)	384	49	22.47	+	2.18	1.79E-06	2.46E-04
regulation of system process (GO:0044057)	393	50	23.00	+	2.17	1.44E-06	2.07E-04
negative regulation of neurogenesis (GO:0050768)	228	29	13.34	+	2.17	2.63E-04	1.62E-02
regulation of stress-activated protein kinase signaling cascade (GO:0070302)	189	24	11.06	+	2.17	1.20E-03	4.96E-02
positive regulation of protein serine/threonine kinase activity (GO:0071902)	268	34	15.68	+	2.17	9.88E-05	7.59E-03
epithelium development (GO:0060429)	718	91	42.01	+	2.17	7.19E-11	3.72E-08
neuron projection morphogenesis (GO:0048812)	379	48	22.18	+	2.16	2.70E-06	3.49E-04
regulation of MAP kinase activity (GO:0043405)	277	35	16.21	+	2.16	7.57E-05	6.07E-03
taxis (GO:0042330)	388	49	22.70	+	2.16	2.18E-06	2.89E-04
negative regulation of cell migration (GO:0030336)	214	27	12.52	+	2.16	5.02E-04	2.54E-02
embryonic organ development (GO:0048568)	325	41	19.02	+	2.16	2.16E-05	2.05E-03
cardiovascular system development (GO:0072358)	444	56	25.98	+	2.16	4.36E-07	7.19E-05
cell part morphogenesis (GO:0032990)	405	51	23.70	+	2.15	1.85E-06	2.50E-04
axon guidance (GO:0007411)	199	25	11.64	+	2.15	9.32E-04	4.09E-02
cell morphogenesis involved in neuron differentiation (GO:0048667)	335	42	19.60	+	2.14	1.70E-05	1.66E-03
neuron projection guidance (GO:0097485)	200	25	11.70	+	2.14	9.64E-04	4.18E-02
positive regulation of kinase activity (GO:0033674)	465	58	27.21	+	2.13	4.37E-07	7.12E-05
negative regulation of cell development (GO:0010721)	265	33	15.51	+	2.13	1.55E-04	1.08E-02
cell morphogenesis (GO:0000902)	555	69	32.48	+	2.12	3.11E-08	7.90E-06
activation of protein kinase activity (GO:0032147)	266	33	15.56	+	2.12	1.61E-04	1.09E-02
negative regulation of cellular component movement (GO:0051271)	258	32	15.10	+	2.12	2.14E-04	1.39E-02
regulation of cation transmembrane transport (GO:1904062)	242	30	14.16	+	2.12	3.88E-04	2.13E-02
negative regulation of cell motility (GO:2000146)	226	28	13.22	+	2.12	4.55E-04	2.37E-02
gland development (GO:0048732)	315	39	18.43	+	2.12	4.61E-05	4.02E-03
cell morphogenesis involved in differentiation (GO:0000904)	437	54	25.57	+	2.11	1.59E-06	2.28E-04
regulation of vasculature development (GO:1901342)	259	32	15.16	+	2.11	2.21E-04	1.42E-02
animal organ morphogenesis (GO:0009887)	697	86	40.78	+	2.11	9.41E-10	3.53E-07
response to hypoxia (GO:0001666)	253	31	14.80	+	2.09	3.15E-04	1.85E-02
embryonic organ morphogenesis (GO:0048562)	213	26	12.46	+	2.09	8.93E-04	3.93E-02
negative regulation of nervous system development (GO:0051961)	246	30	14.39	+	2.08	4.34E-04	2.28E-02
positive regulation of protein kinase activity (GO:0045860)	427	52	24.99	+	2.08	3.40E-06	4.32E-04
chemotaxis (GO:0006935)	386	47	22.59	+	2.08	9.20E-06	9.85E-04
response to decreased oxygen levels (GO:0036293)	264	32	15.45	+	2.07	2.69E-04	1.64E-02
extracellular matrix organization (GO:0030198)	256	31	14.98	+	2.07	3.52E-04	1.99E-02
regulation of epithelial cell proliferation (GO:0050678)	257	31	15.04	+	2.06	3.67E-04	2.05E-02
positive regulation of nervous system development (GO:0051962)	423	51	24.75	+	2.06	5.15E-06	6.28E-04
morphogenesis of an epithelium (GO:0002009)	324	39	18.96	+	2.06	6.47E-05	5.27E-03
cellular component morphogenesis (GO:0032989)	632	76	36.98	+	2.06	2.77E-08	7.42E-06
circulatory system development (GO:0072359)	710	85	41.55	+	2.05	3.72E-09	1.14E-06
axon development (GO:0061564)	318	38	18.61	+	2.04	9.19E-05	7.14E-03
axonogenesis (GO:0007409)	285	34	16.68	+	2.04	2.63E-04	1.62E-02
cell migration (GO:0016477)	656	78	38.39	+	2.03	3.03E-08	7.97E-06
angiogenesis (GO:0001525)	270	32	15.80	+	2.03	4.81E-04	2.46E-02
extracellular structure organization (GO:0043062)	287	34	16.79	+	2.02	2.80E-04	1.69E-02
negative regulation of multicellular organismal process (GO:0051241)	929	110	54.36	+	2.02	2.32E-11	1.29E-08
positive regulation of protein phosphorylation (GO:0001934)	778	92	45.52	+	2.02	1.55E-09	5.28E-07
positive regulation of phosphorylation (GO:0042327)	821	97	48.04	+	2.02	5.97E-10	2.42E-07
positive regulation of cell adhesion (GO:0045785)	314	37	18.37	+	2.01	1.99E-04	1.31E-02
negative regulation of cell differentiation (GO:0045596)	538	63	31.48	+	2.00	1.00E-06	1.52E-04
lymphocyte activation (GO:0046649)	282	33	16.50	+	2.00	4.09E-04	2.22E-02
modulation of chemical synaptic transmission (GO:0050804)	343	40	20.07	+	1.99	1.01E-04	7.71E-03
regulation of trans-synaptic signaling (GO:0099177)	344	40	20.13	+	1.99	1.05E-04	7.98E-03
response to oxygen levels (GO:0070482)	284	33	16.62	+	1.99	4.41E-04	2.31E-02
regulation of anatomical structure morphogenesis (GO:0022603)	838	97	49.03	+	1.98	1.41E-09	4.92E-07
sensory system development (GO:0048880)	268	31	15.68	+	1.98	7.57E-04	3.46E-02
positive regulation of phosphorus metabolic process (GO:0010562)	874	101	51.14	+	1.97	7.35E-10	2.90E-07
positive regulation of phosphate metabolic process (GO:0045937)	874	101	51.14	+	1.97	7.35E-10	2.82E-07
behavior (GO:0007610)	425	49	24.87	+	1.97	2.30E-05	2.17E-03
neuron development (GO:0048666)	645	74	37.74	+	1.96	2.44E-07	4.51E-05
in utero embryonic development (GO:0001701)	279	32	16.33	+	1.96	6.44E-04	3.04E-02
positive regulation of transferase activity (GO:0051347)	535	61	31.31	+	1.95	3.68E-06	4.63E-04
regulation of cell adhesion (GO:0030155)	535	61	31.31	+	1.95	3.68E-06	4.59E-04
embryo development (GO:0009790)	737	84	43.12	+	1.95	4.23E-08	1.02E-05
eye development (GO:0001654)	264	30	15.45	+	1.94	1.13E-03	4.78E-02
visual system development (GO:0150063)	264	30	15.45	+	1.94	1.13E-03	4.76E-02
positive regulation of neurogenesis (GO:0050769)	379	43	22.18	+	1.94	1.28E-04	9.34E-03
embryonic morphogenesis (GO:0048598)	432	49	25.28	+	1.94	4.01E-05	3.55E-03
muscle structure development (GO:0061061)	371	42	21.71	+	1.93	1.70E-04	1.15E-02
developmental process involved in reproduction (GO:0003006)	490	55	28.67	+	1.92	1.45E-05	1.46E-03
positive regulation of multicellular organismal process (GO:0051240)	1311	147	76.71	+	1.92	2.92E-13	3.13E-10
neuron differentiation (GO:0030182)	767	86	44.88	+	1.92	4.98E-08	1.15E-05
neuron projection development (GO:0031175)	537	60	31.42	+	1.91	6.37E-06	7.34E-04
locomotion (GO:0040011)	931	104	54.48	+	1.91	2.24E-09	7.14E-07
localization of cell (GO:0051674)	737	82	43.12	+	1.90	1.58E-07	3.12E-05
cell motility (GO:0048870)	737	82	43.12	+	1.90	1.58E-07	3.08E-05
tissue development (GO:0009888)	1205	134	70.51	+	1.90	8.59E-12	5.15E-09
actin filament-based process (GO:0030029)	475	52	27.79	+	1.87	5.80E-05	4.83E-03
negative regulation of cell proliferation (GO:0008285)	541	59	31.66	+	1.86	1.56E-05	1.54E-03
regulation of neurogenesis (GO:0050767)	664	72	38.85	+	1.85	2.04E-06	2.73E-04
regulation of MAPK cascade (GO:0043408)	601	65	35.17	+	1.85	8.04E-06	8.79E-04
actin cytoskeleton organization (GO:0030036)	426	46	24.93	+	1.85	1.98E-04	1.32E-02
cellular response to organic cyclic compound (GO:0071407)	389	42	22.76	+	1.85	3.65E-04	2.05E-02
movement of cell or subcellular component (GO:0006928)	1122	121	65.65	+	1.84	5.59E-10	2.33E-07
wound healing (GO:0042060)	362	39	21.18	+	1.84	5.52E-04	2.71E-02
regulation of nervous system development (GO:0051960)	745	80	43.59	+	1.84	9.56E-07	1.48E-04
protein phosphorylation (GO:0006468)	820	88	47.98	+	1.83	1.97E-07	3.73E-05
cell adhesion (GO:0007155)	727	78	42.54	+	1.83	1.10E-06	1.64E-04
sensory organ development (GO:0007423)	392	42	22.94	+	1.83	3.94E-04	2.15E-02
embryo development ending in birth or egg hatching (GO:0009792)	497	53	29.08	+	1.82	8.38E-05	6.61E-03
biological adhesion (GO:0022610)	732	78	42.83	+	1.82	1.73E-06	2.40E-04
positive regulation of cell development (GO:0010720)	432	46	25.28	+	1.82	2.29E-04	1.46E-02
cell-cell adhesion (GO:0098609)	387	41	22.64	+	1.81	5.53E-04	2.71E-02
chordate embryonic development (GO:0043009)	482	51	28.20	+	1.81	1.45E-04	1.04E-02
anatomical structure formation involved in morphogenesis (GO:0048646)	691	73	40.43	+	1.81	4.52E-06	5.60E-04
positive regulation of developmental process (GO:0051094)	1063	112	62.20	+	1.80	8.79E-09	2.54E-06
positive regulation of cell proliferation (GO:0008284)	688	72	40.26	+	1.79	6.56E-06	7.46E-04
generation of neurons (GO:0048699)	1210	126	70.80	+	1.78	2.04E-09	6.64E-07
regulation of multicellular organismal process (GO:0051239)	2364	246	138.33	+	1.78	9.22E-19	1.38E-14
negative regulation of developmental process (GO:0051093)	732	76	42.83	+	1.77	5.51E-06	6.56E-04
anatomical structure morphogenesis (GO:0009653)	1633	169	95.55	+	1.77	2.34E-12	1.75E-09
regulation of multicellular organismal development (GO:2000026)	1578	163	92.34	+	1.77	8.04E-12	5.02E-09
regulation of cell development (GO:0060284)	757	78	44.30	+	1.76	5.33E-06	6.45E-04
cell development (GO:0048468)	1255	129	73.44	+	1.76	2.54E-09	7.94E-07
positive regulation of protein modification process (GO:0031401)	976	100	57.11	+	1.75	2.54E-07	4.65E-05
neurogenesis (GO:0022008)	1290	132	75.48	+	1.75	1.90E-09	6.33E-07
regulation of anatomical structure size (GO:0090066)	431	44	25.22	+	1.74	7.23E-04	3.32E-02
cell-cell signaling (GO:0007267)	749	76	43.83	+	1.73	1.03E-05	1.08E-03
regulation of protein serine/threonine kinase activity (GO:0071900)	424	43	24.81	+	1.73	9.48E-04	4.12E-02
response to wounding (GO:0009611)	434	44	25.40	+	1.73	1.03E-03	4.38E-02
regulation of ion transport (GO:0043269)	484	49	28.32	+	1.73	4.70E-04	2.42E-02
regulation of protein phosphorylation (GO:0001932)	1147	116	67.12	+	1.73	3.94E-08	9.67E-06
positive regulation of cell differentiation (GO:0045597)	766	77	44.82	+	1.72	1.26E-05	1.29E-03
regulation of neuron differentiation (GO:0045664)	539	54	31.54	+	1.71	3.19E-04	1.86E-02
cell proliferation (GO:0008283)	559	56	32.71	+	1.71	2.11E-04	1.38E-02
positive regulation of intracellular signal transduction (GO:1902533)	841	84	49.21	+	1.71	5.51E-06	6.60E-04
regulation of phosphorylation (GO:0042325)	1248	124	73.03	+	1.70	3.10E-08	8.01E-06
plasma membrane bounded cell projection organization (GO:0120036)	926	92	54.18	+	1.70	2.49E-06	3.28E-04
regulation of developmental process (GO:0050793)	2022	200	118.32	+	1.69	5.77E-13	5.77E-10
regulation of cell differentiation (GO:0045595)	1391	137	81.39	+	1.68	8.97E-09	2.54E-06
regulation of cell proliferation (GO:0042127)	1240	122	72.56	+	1.68	7.94E-08	1.73E-05
regulation of kinase activity (GO:0043549)	725	71	42.42	+	1.67	6.24E-05	5.11E-03
regulation of growth (GO:0040008)	576	56	33.70	+	1.66	4.88E-04	2.48E-02
cytoskeleton organization (GO:0007010)	947	92	55.41	+	1.66	6.15E-06	7.15E-04
regulation of localization (GO:0032879)	2139	207	125.16	+	1.65	1.37E-12	1.14E-09
positive regulation of signal transduction (GO:0009967)	1271	123	74.37	+	1.65	1.54E-07	3.09E-05
positive regulation of cell communication (GO:0010647)	1385	134	81.04	+	1.65	3.39E-08	8.47E-06
central nervous system development (GO:0007417)	736	71	43.07	+	1.65	9.76E-05	7.54E-03
regulation of protein kinase activity (GO:0045859)	657	63	38.44	+	1.64	3.05E-04	1.80E-02
intracellular signal transduction (GO:0035556)	1389	133	81.28	+	1.64	6.86E-08	1.54E-05
negative regulation of response to stimulus (GO:0048585)	1309	125	76.59	+	1.63	2.25E-07	4.22E-05
positive regulation of signaling (GO:0023056)	1393	133	81.51	+	1.63	9.71E-08	2.08E-05
cell projection organization (GO:0030030)	964	92	56.41	+	1.63	1.39E-05	1.40E-03
cell differentiation (GO:0030154)	2706	258	158.34	+	1.63	3.10E-15	9.29E-12
cell surface receptor signaling pathway (GO:0007166)	1744	166	102.05	+	1.63	1.38E-09	4.93E-07
nervous system development (GO:0007399)	1853	176	108.43	+	1.62	4.92E-10	2.11E-07
cellular developmental process (GO:0048869)	2782	264	162.79	+	1.62	2.08E-15	7.79E-12
positive regulation of catalytic activity (GO:0043085)	1192	113	69.75	+	1.62	1.36E-06	1.99E-04
positive regulation of immune system process (GO:0002684)	678	64	39.67	+	1.61	3.79E-04	2.10E-02
response to external stimulus (GO:0009605)	1434	135	83.91	+	1.61	1.42E-07	2.96E-05
response to organic cyclic compound (GO:0014070)	661	62	38.68	+	1.60	5.94E-04	2.85E-02
regulation of immune response (GO:0050776)	661	62	38.68	+	1.60	5.94E-04	2.84E-02
negative regulation of apoptotic process (GO:0043066)	738	69	43.18	+	1.60	3.47E-04	1.97E-02
regulation of phosphate metabolic process (GO:0019220)	1417	132	82.91	+	1.59	3.22E-07	5.75E-05
regulation of phosphorus metabolic process (GO:0051174)	1419	132	83.03	+	1.59	4.32E-07	7.20E-05
negative regulation of signal transduction (GO:0009968)	1030	95	60.27	+	1.58	3.35E-05	3.04E-03
positive regulation of molecular function (GO:0044093)	1480	136	86.60	+	1.57	5.20E-07	8.30E-05
negative regulation of programmed cell death (GO:0043069)	751	69	43.94	+	1.57	5.20E-04	2.62E-02
negative regulation of cell death (GO:0060548)	822	75	48.10	+	1.56	2.94E-04	1.74E-02
signaling (GO:0023052)	3650	332	213.58	+	1.55	1.54E-17	1.15E-13
cellular response to oxygen-containing compound (GO:1901701)	774	70	45.29	+	1.55	6.31E-04	3.00E-02
animal organ development (GO:0048513)	2300	208	134.58	+	1.55	3.95E-10	1.74E-07
programmed cell death (GO:0012501)	831	75	48.63	+	1.54	4.15E-04	2.24E-02
regulation of cell communication (GO:0010646)	2841	256	166.24	+	1.54	1.99E-12	1.57E-09
negative regulation of cell communication (GO:0010648)	1101	99	64.42	+	1.54	5.72E-05	4.79E-03
cell communication (GO:0007154)	3741	336	218.90	+	1.53	4.15E-17	2.07E-13
negative regulation of signaling (GO:0023057)	1104	99	64.60	+	1.53	5.86E-05	4.86E-03
phosphorylation (GO:0016310)	1116	100	65.30	+	1.53	4.94E-05	4.18E-03
positive regulation of transcription by RNA polymerase II (GO:0045944)	949	85	55.53	+	1.53	2.38E-04	1.50E-02
system development (GO:0048731)	3318	297	194.15	+	1.53	2.13E-14	4.55E-11
regulation of transferase activity (GO:0051338)	827	74	48.39	+	1.53	6.93E-04	3.22E-02
signal transduction (GO:0007165)	3413	305	199.71	+	1.53	7.71E-15	1.93E-11
positive regulation of response to stimulus (GO:0048584)	1713	153	100.23	+	1.53	3.69E-07	6.37E-05
regulation of signaling (GO:0023051)	2874	256	168.17	+	1.52	6.29E-12	4.28E-09
cell death (GO:0008219)	865	77	50.61	+	1.52	5.26E-04	2.64E-02
reproductive process (GO:0022414)	1037	92	60.68	+	1.52	1.48E-04	1.04E-02
regulation of signal transduction (GO:0009966)	2561	227	149.85	+	1.51	2.70E-10	1.31E-07
reproduction (GO:0000003)	1039	92	60.80	+	1.51	1.52E-04	1.07E-02
regulation of intracellular signal transduction (GO:1902531)	1540	135	90.11	+	1.50	5.74E-06	6.73E-04
regulation of immune system process (GO:0002682)	1062	93	62.14	+	1.50	2.25E-04	1.43E-02
positive regulation of protein metabolic process (GO:0051247)	1382	121	80.87	+	1.50	1.88E-05	1.83E-03
positive regulation of cellular protein metabolic process (GO:0032270)	1298	113	75.95	+	1.49	5.35E-05	4.50E-03
multicellular organism development (GO:0007275)	3757	325	219.84	+	1.48	3.99E-14	6.65E-11
cellular response to endogenous stimulus (GO:0071495)	932	80	54.54	+	1.47	1.06E-03	4.49E-02
regulation of protein modification process (GO:0031399)	1503	128	87.95	+	1.46	3.70E-05	3.32E-03
anatomical structure development (GO:0048856)	4039	343	236.34	+	1.45	4.76E-14	6.48E-11
positive regulation of cellular component organization (GO:0051130)	1057	89	61.85	+	1.44	9.89E-04	4.26E-02
regulation of apoptotic process (GO:0042981)	1260	106	73.73	+	1.44	3.19E-04	1.85E-02
regulation of transport (GO:0051049)	1409	118	82.45	+	1.43	1.59E-04	1.10E-02
developmental process (GO:0032502)	4313	361	252.37	+	1.43	4.57E-14	6.85E-11
positive regulation of transcription, DNA-templated (GO:0045893)	1234	103	72.21	+	1.43	5.66E-04	2.76E-02
positive regulation of gene expression (GO:0010628)	1595	133	93.33	+	1.43	7.29E-05	5.88E-03
regulation of programmed cell death (GO:0043067)	1273	106	74.49	+	1.42	4.34E-04	2.29E-02
regulation of response to stimulus (GO:0048583)	3256	271	190.52	+	1.42	1.06E-09	3.87E-07
positive regulation of macromolecule metabolic process (GO:0010604)	2705	224	158.28	+	1.42	9.81E-08	2.07E-05
cellular response to organic substance (GO:0071310)	1764	146	103.22	+	1.41	3.85E-05	3.43E-03
positive regulation of nitrogen compound metabolic process (GO:0051173)	2584	213	151.20	+	1.41	3.27E-07	5.77E-05
positive regulation of metabolic process (GO:0009893)	2918	239	170.74	+	1.40	6.87E-08	1.51E-05
positive regulation of cellular metabolic process (GO:0031325)	2681	219	156.88	+	1.40	3.84E-07	6.54E-05
regulation of cell death (GO:0010941)	1376	112	80.52	+	1.39	6.73E-04	3.15E-02
multicellular organismal process (GO:0032501)	4793	390	280.46	+	1.39	1.06E-13	1.33E-10
regulation of cellular component organization (GO:0051128)	2183	177	127.74	+	1.39	1.37E-05	1.40E-03
cellular response to chemical stimulus (GO:0070887)	2153	173	125.98	+	1.37	2.95E-05	2.72E-03
regulation of biological quality (GO:0065008)	3127	251	182.97	+	1.37	1.46E-07	2.99E-05
positive regulation of cellular biosynthetic process (GO:0031328)	1595	128	93.33	+	1.37	4.33E-04	2.29E-02
positive regulation of biosynthetic process (GO:0009891)	1620	130	94.79	+	1.37	3.85E-04	2.12E-02
positive regulation of cellular process (GO:0048522)	4248	339	248.57	+	1.36	2.73E-10	1.28E-07
positive regulation of biological process (GO:0048518)	4741	378	277.42	+	1.36	6.99E-12	4.55E-09
regulation of molecular function (GO:0065009)	2596	205	151.90	+	1.35	1.01E-05	1.06E-03
immune system process (GO:0002376)	1813	142	106.09	+	1.34	5.88E-04	2.83E-02
regulation of catalytic activity (GO:0050790)	1923	147	112.52	+	1.31	1.16E-03	4.85E-02
cellular response to stimulus (GO:0051716)	4737	361	277.18	+	1.30	9.27E-09	2.57E-06
negative regulation of biological process (GO:0048519)	4260	324	249.27	+	1.30	1.64E-07	3.15E-05
response to organic substance (GO:0010033)	2252	169	131.77	+	1.28	1.03E-03	4.38E-02
negative regulation of cellular process (GO:0048523)	3791	283	221.83	+	1.28	7.50E-06	8.26E-04
response to chemical (GO:0042221)	3040	224	177.88	+	1.26	2.68E-04	1.64E-02
response to stimulus (GO:0050896)	5945	424	347.87	+	1.22	5.82E-07	9.09E-05
regulation of cellular process (GO:0050794)	8281	586	484.56	+	1.21	3.35E-11	1.80E-08
regulation of biological process (GO:0050789)	8845	619	517.56	+	1.20	1.72E-11	9.92E-09
regulation of nitrogen compound metabolic process (GO:0051171)	4786	334	280.05	+	1.19	2.18E-04	1.41E-02
regulation of primary metabolic process (GO:0080090)	4932	344	288.59	+	1.19	1.59E-04	1.10E-02
cellular component organization (GO:0016043)	4719	329	276.13	+	1.19	2.76E-04	1.67E-02
biological regulation (GO:0065007)	9384	651	549.10	+	1.19	5.28E-12	3.77E-09
regulation of cellular metabolic process (GO:0031323)	5042	346	295.03	+	1.17	5.33E-04	2.66E-02
regulation of metabolic process (GO:0019222)	5454	372	319.14	+	1.17	3.97E-04	2.16E-02
regulation of macromolecule metabolic process (GO:0060255)	5020	342	293.74	+	1.16	1.02E-03	4.35E-02
cellular process (GO:0009987)	11157	700	652.84	+	1.07	5.26E-04	2.65E-02
cellular aromatic compound metabolic process (GO:0006725)	2835	127	165.89	-	.77	8.52E-04	3.76E-02
organic cyclic compound metabolic process (GO:1901360)	2998	133	175.43	-	.76	4.16E-04	2.24E-02
cellular nitrogen compound metabolic process (GO:0034641)	3213	142	188.01	-	.76	1.87E-04	1.25E-02
nucleobase-containing compound metabolic process (GO:0006139)	2679	117	156.76	-	.75	5.38E-04	2.67E-02
heterocycle metabolic process (GO:0046483)	2810	122	164.42	-	.74	2.49E-04	1.55E-02
gene expression (GO:0010467)	1825	73	106.79	-	.68	4.14E-04	2.24E-02
mRNA metabolic process (GO:0016071)	643	16	37.62	-	.43	1.18E-04	8.82E-03
RNA processing (GO:0006396)	798	16	46.69	-	.34	3.67E-07	6.40E-05
RNA splicing (GO:0008380)	372	6	21.77	-	.28	1.48E-04	1.05E-02
mRNA processing (GO:0006397)	435	7	25.45	-	.28	4.74E-05	4.06E-03
nucleobase-containing compound transport (GO:0015931)	217	2	12.70	-	.16	8.21E-04	3.66E-02
RNA transport (GO:0050658)	182	1	10.65	-	.09	8.35E-04	3.71E-02
nucleic acid transport (GO:0050657)	182	1	10.65	-	.09	8.35E-04	3.70E-02
establishment of RNA localization (GO:0051236)	184	1	10.77	-	.09	5.33E-04	2.65E-02
protein folding (GO:0006457)	198	1	11.59	-	.09	2.51E-04	1.55E-02
RNA localization (GO:0006403)	205	1	12.00	-	.08	1.72E-04	1.16E-02