Analysis Type: PANTHER Overrepresentation Test (Released 20181113) Annotation Version and Release Date: GO Ontology database Released 2018-10-08 Analyzed List: T19C1_DOWN_0.1.genes (Homo sapiens) There are duplicate IDs in the file. The unique set of IDs will be used. Reference List: background.genes (Homo sapiens) There are duplicate IDs in the file. The unique set of IDs will be used. Test Type: FISHER Correction: FDR GO biological process complete background.genes - REFLIST (15398) T19C1_DOWN_0.1.genes (2599) T19C1_DOWN_0.1.genes (expected) T19C1_DOWN_0.1.genes (over/under) T19C1_DOWN_0.1.genes (fold Enrichment) T19C1_DOWN_0.1.genes (raw P-value) T19C1_DOWN_0.1.genes (FDR) cranial nerve morphogenesis (GO:0021602) 23 13 3.88 + 3.35 1.02E-03 4.57E-02 protein localization to cytoskeleton (GO:0044380) 36 18 6.08 + 2.96 5.90E-04 2.86E-02 coronary vasculature development (GO:0060976) 40 20 6.75 + 2.96 2.65E-04 1.48E-02 regulation of cell migration involved in sprouting angiogenesis (GO:0090049) 36 17 6.08 + 2.80 1.14E-03 4.87E-02 lamellipodium assembly (GO:0030032) 36 17 6.08 + 2.80 1.14E-03 4.85E-02 renal tubule morphogenesis (GO:0061333) 45 21 7.60 + 2.76 2.95E-04 1.61E-02 renal tubule development (GO:0061326) 53 24 8.95 + 2.68 2.24E-04 1.29E-02 cellular component maintenance (GO:0043954) 40 18 6.75 + 2.67 1.09E-03 4.71E-02 nephron tubule development (GO:0072080) 50 22 8.44 + 2.61 5.31E-04 2.63E-02 microtubule cytoskeleton organization involved in mitosis (GO:1902850) 98 41 16.54 + 2.48 4.49E-06 5.26E-04 vascular endothelial growth factor receptor signaling pathway (GO:0048010) 63 26 10.63 + 2.45 3.62E-04 1.91E-02 embryonic heart tube development (GO:0035050) 54 22 9.11 + 2.41 9.15E-04 4.12E-02 regulation of mitotic sister chromatid separation (GO:0010965) 57 23 9.62 + 2.39 1.09E-03 4.71E-02 mitotic spindle organization (GO:0007052) 75 30 12.66 + 2.37 2.13E-04 1.24E-02 regulation of chromosome separation (GO:1905818) 60 24 10.13 + 2.37 8.26E-04 3.78E-02 embryonic skeletal system morphogenesis (GO:0048704) 75 30 12.66 + 2.37 2.13E-04 1.24E-02 actin cytoskeleton reorganization (GO:0031532) 60 24 10.13 + 2.37 8.26E-04 3.77E-02 regulation of Rho protein signal transduction (GO:0035023) 120 48 20.25 + 2.37 2.21E-06 2.78E-04 positive regulation of mitotic cell cycle phase transition (GO:1901992) 68 27 11.48 + 2.35 3.60E-04 1.91E-02 postsynapse organization (GO:0099173) 79 31 13.33 + 2.32 1.78E-04 1.08E-02 regulation of cytokinesis (GO:0032465) 69 27 11.65 + 2.32 6.26E-04 3.02E-02 regulation of actin filament bundle assembly (GO:0032231) 87 34 14.68 + 2.32 8.05E-05 5.67E-03 regulation of stress fiber assembly (GO:0051492) 75 29 12.66 + 2.29 3.61E-04 1.91E-02 regulation of actomyosin structure organization (GO:0110020) 83 32 14.01 + 2.28 1.61E-04 1.01E-02 regulation of blood vessel endothelial cell migration (GO:0043535) 83 32 14.01 + 2.28 1.61E-04 1.01E-02 regulation of small GTPase mediated signal transduction (GO:0051056) 303 116 51.14 + 2.27 1.31E-12 1.23E-09 regulation of osteoblast differentiation (GO:0045667) 84 32 14.18 + 2.26 2.63E-04 1.47E-02 mitotic sister chromatid segregation (GO:0000070) 104 39 17.55 + 2.22 6.06E-05 4.64E-03 sister chromatid segregation (GO:0000819) 129 48 21.77 + 2.20 1.21E-05 1.19E-03 positive regulation of GTPase activity (GO:0043547) 359 133 60.59 + 2.19 2.13E-13 2.90E-10 regulation of embryonic development (GO:0045995) 100 37 16.88 + 2.19 1.20E-04 7.97E-03 regulation of endothelial cell migration (GO:0010594) 136 50 22.96 + 2.18 7.98E-06 8.36E-04 branching morphogenesis of an epithelial tube (GO:0048754) 98 36 16.54 + 2.18 1.68E-04 1.04E-02 regulation of Ras protein signal transduction (GO:0046578) 206 75 34.77 + 2.16 7.10E-08 1.64E-05 positive regulation of cell cycle phase transition (GO:1901989) 80 29 13.50 + 2.15 8.59E-04 3.88E-02 spindle organization (GO:0007051) 130 47 21.94 + 2.14 2.16E-05 1.92E-03 regulation of GTPase activity (GO:0043087) 430 155 72.58 + 2.14 8.44E-15 2.53E-11 mitotic nuclear division (GO:0140014) 140 50 23.63 + 2.12 1.61E-05 1.51E-03 embryonic skeletal system development (GO:0048706) 96 34 16.20 + 2.10 3.95E-04 2.07E-02 regulation of epithelial cell migration (GO:0010632) 190 66 32.07 + 2.06 1.55E-06 2.09E-04 regulation of chromosome segregation (GO:0051983) 98 34 16.54 + 2.06 6.60E-04 3.17E-02 establishment of cell polarity (GO:0030010) 98 34 16.54 + 2.06 6.60E-04 3.16E-02 positive regulation of endothelial cell migration (GO:0010595) 90 31 15.19 + 2.04 1.06E-03 4.63E-02 positive regulation of epithelial cell migration (GO:0010634) 125 43 21.10 + 2.04 1.44E-04 9.17E-03 anatomical structure maturation (GO:0071695) 99 34 16.71 + 2.03 7.05E-04 3.34E-02 limb development (GO:0060173) 129 43 21.77 + 1.97 2.69E-04 1.50E-02 appendage development (GO:0048736) 129 43 21.77 + 1.97 2.69E-04 1.49E-02 regulation of ossification (GO:0030278) 138 46 23.29 + 1.97 1.30E-04 8.48E-03 morphogenesis of a branching structure (GO:0001763) 124 41 20.93 + 1.96 4.80E-04 2.39E-02 limb morphogenesis (GO:0035108) 106 35 17.89 + 1.96 1.03E-03 4.59E-02 appendage morphogenesis (GO:0035107) 106 35 17.89 + 1.96 1.03E-03 4.57E-02 epithelial tube morphogenesis (GO:0060562) 237 78 40.00 + 1.95 9.73E-07 1.49E-04 anterior/posterior pattern specification (GO:0009952) 152 50 25.66 + 1.95 1.08E-04 7.31E-03 central nervous system neuron differentiation (GO:0021953) 119 39 20.09 + 1.94 5.80E-04 2.82E-02 regulation of mitotic nuclear division (GO:0007088) 165 54 27.85 + 1.94 6.05E-05 4.65E-03 bone development (GO:0060348) 148 48 24.98 + 1.92 1.99E-04 1.17E-02 embryonic organ morphogenesis (GO:0048562) 213 69 35.95 + 1.92 7.23E-06 7.68E-04 pattern specification process (GO:0007389) 301 97 50.81 + 1.91 1.08E-07 2.24E-05 nuclear chromosome segregation (GO:0098813) 193 62 32.58 + 1.90 3.01E-05 2.58E-03 regulation of microtubule cytoskeleton organization (GO:0070507) 170 54 28.69 + 1.88 1.12E-04 7.50E-03 protein autophosphorylation (GO:0046777) 164 52 27.68 + 1.88 1.84E-04 1.11E-02 axon guidance (GO:0007411) 199 63 33.59 + 1.88 3.88E-05 3.23E-03 neural tube development (GO:0021915) 136 43 22.96 + 1.87 5.72E-04 2.81E-02 regulation of nuclear division (GO:0051783) 184 58 31.06 + 1.87 6.72E-05 5.01E-03 neuron projection guidance (GO:0097485) 200 63 33.76 + 1.87 4.02E-05 3.30E-03 skeletal system morphogenesis (GO:0048705) 182 57 30.72 + 1.86 9.00E-05 6.22E-03 positive regulation of mitotic cell cycle (GO:0045931) 132 41 22.28 + 1.84 1.03E-03 4.56E-02 telencephalon development (GO:0021537) 201 62 33.93 + 1.83 8.69E-05 6.06E-03 negative regulation of cell migration (GO:0030336) 214 66 36.12 + 1.83 4.80E-05 3.85E-03 microtubule cytoskeleton organization (GO:0000226) 419 129 70.72 + 1.82 1.01E-08 2.80E-06 chromosome segregation (GO:0007059) 242 74 40.85 + 1.81 1.65E-05 1.55E-03 positive regulation of neuron differentiation (GO:0045666) 293 89 49.45 + 1.80 3.01E-06 3.64E-04 morphogenesis of an epithelium (GO:0002009) 324 98 54.69 + 1.79 1.10E-06 1.59E-04 regionalization (GO:0003002) 225 68 37.98 + 1.79 5.13E-05 4.05E-03 regulation of microtubule-based process (GO:0032886) 199 60 33.59 + 1.79 1.63E-04 1.02E-02 negative regulation of cell motility (GO:2000146) 226 68 38.15 + 1.78 7.34E-05 5.29E-03 cell division (GO:0051301) 459 138 77.47 + 1.78 9.95E-09 2.82E-06 heart morphogenesis (GO:0003007) 187 56 31.56 + 1.77 3.06E-04 1.66E-02 nuclear division (GO:0000280) 257 76 43.38 + 1.75 3.75E-05 3.14E-03 negative regulation of cellular component movement (GO:0051271) 258 76 43.55 + 1.75 3.92E-05 3.24E-03 regulation of cell cycle G2/M phase transition (GO:1902749) 163 48 27.51 + 1.74 1.08E-03 4.70E-02 renal system development (GO:0072001) 214 63 36.12 + 1.74 1.92E-04 1.14E-02 regulation of cell-substrate adhesion (GO:0010810) 177 52 29.88 + 1.74 8.43E-04 3.83E-02 tissue morphogenesis (GO:0048729) 423 124 71.40 + 1.74 1.73E-07 3.37E-05 neuron projection morphogenesis (GO:0048812) 379 111 63.97 + 1.74 8.54E-07 1.36E-04 positive regulation of neurogenesis (GO:0050769) 379 111 63.97 + 1.74 8.54E-07 1.35E-04 regulation of cell migration (GO:0030334) 683 200 115.28 + 1.73 2.44E-11 1.40E-08 cell morphogenesis involved in neuron differentiation (GO:0048667) 335 98 56.54 + 1.73 4.20E-06 4.99E-04 cytoskeleton organization (GO:0007010) 947 277 159.84 + 1.73 2.09E-15 1.57E-11 positive regulation of cell development (GO:0010720) 432 126 72.92 + 1.73 1.65E-07 3.26E-05 cell projection morphogenesis (GO:0048858) 384 112 64.81 + 1.73 9.88E-07 1.50E-04 developmental growth (GO:0048589) 295 86 49.79 + 1.73 1.70E-05 1.59E-03 forebrain development (GO:0030900) 292 85 49.29 + 1.72 2.13E-05 1.95E-03 actin filament-based process (GO:0030029) 475 138 80.17 + 1.72 6.05E-08 1.42E-05 synapse organization (GO:0050808) 217 63 36.63 + 1.72 2.88E-04 1.58E-02 negative regulation of locomotion (GO:0040013) 269 78 45.40 + 1.72 5.37E-05 4.20E-03 plasma membrane bounded cell projection morphogenesis (GO:0120039) 383 111 64.65 + 1.72 1.32E-06 1.80E-04 actin cytoskeleton organization (GO:0030036) 426 123 71.90 + 1.71 3.63E-07 6.41E-05 tube morphogenesis (GO:0035239) 534 154 90.13 + 1.71 1.35E-08 3.54E-06 cardiovascular system development (GO:0072358) 444 128 74.94 + 1.71 2.32E-07 4.29E-05 growth (GO:0040007) 299 86 50.47 + 1.70 2.62E-05 2.27E-03 regulation of cellular component movement (GO:0051270) 797 229 134.52 + 1.70 3.55E-12 2.80E-09 blood vessel development (GO:0001568) 413 118 69.71 + 1.69 1.19E-06 1.65E-04 organelle fission (GO:0048285) 280 80 47.26 + 1.69 7.33E-05 5.33E-03 regulation of cell motility (GO:2000145) 729 208 123.05 + 1.69 6.35E-11 3.17E-08 positive regulation of neuron projection development (GO:0010976) 235 67 39.67 + 1.69 2.59E-04 1.45E-02 vasculature development (GO:0001944) 435 124 73.42 + 1.69 6.25E-07 1.05E-04 axonogenesis (GO:0007409) 285 81 48.10 + 1.68 6.24E-05 4.73E-03 heart development (GO:0007507) 412 117 69.54 + 1.68 1.57E-06 2.08E-04 cell part morphogenesis (GO:0032990) 405 115 68.36 + 1.68 1.79E-06 2.30E-04 positive regulation of nervous system development (GO:0051962) 423 120 71.40 + 1.68 1.14E-06 1.63E-04 regulation of mitotic cell cycle phase transition (GO:1901990) 346 98 58.40 + 1.68 1.11E-05 1.11E-03 embryonic organ development (GO:0048568) 325 92 54.86 + 1.68 2.15E-05 1.93E-03 urogenital system development (GO:0001655) 237 67 40.00 + 1.67 3.68E-04 1.93E-02 embryonic morphogenesis (GO:0048598) 432 122 72.92 + 1.67 1.08E-06 1.57E-04 regulation of neuron differentiation (GO:0045664) 539 152 90.98 + 1.67 5.29E-08 1.26E-05 animal organ morphogenesis (GO:0009887) 697 196 117.65 + 1.67 6.03E-10 2.26E-07 camera-type eye development (GO:0043010) 225 63 37.98 + 1.66 6.69E-04 3.19E-02 tube development (GO:0035295) 675 189 113.93 + 1.66 1.59E-09 5.55E-07 positive regulation of cell cycle process (GO:0090068) 243 68 41.02 + 1.66 4.29E-04 2.21E-02 regulation of cell cycle phase transition (GO:1901987) 372 104 62.79 + 1.66 1.14E-05 1.13E-03 regulation of neurogenesis (GO:0050767) 664 184 112.08 + 1.64 5.33E-09 1.60E-06 regulation of locomotion (GO:0040012) 789 218 133.17 + 1.64 2.10E-10 8.74E-08 plasma membrane bounded cell projection assembly (GO:0120031) 391 108 66.00 + 1.64 1.03E-05 1.03E-03 circulatory system development (GO:0072359) 710 196 119.84 + 1.64 2.02E-09 6.74E-07 microtubule-based process (GO:0007017) 589 162 99.42 + 1.63 7.29E-08 1.66E-05 axon development (GO:0061564) 318 87 53.67 + 1.62 1.05E-04 7.14E-03 mitotic cell cycle process (GO:1903047) 573 156 96.72 + 1.61 2.14E-07 4.05E-05 regulation of cell development (GO:0060284) 757 206 127.77 + 1.61 2.38E-09 7.76E-07 positive regulation of cell projection organization (GO:0031346) 324 88 54.69 + 1.61 1.20E-04 7.98E-03 regulation of nervous system development (GO:0051960) 745 202 125.75 + 1.61 4.29E-09 1.34E-06 regulation of cell cycle process (GO:0010564) 642 173 108.36 + 1.60 9.75E-08 2.06E-05 chemotaxis (GO:0006935) 386 104 65.15 + 1.60 3.74E-05 3.15E-03 cell projection assembly (GO:0030031) 405 109 68.36 + 1.59 2.46E-05 2.15E-03 eye development (GO:0001654) 264 71 44.56 + 1.59 7.06E-04 3.33E-02 visual system development (GO:0150063) 264 71 44.56 + 1.59 7.06E-04 3.32E-02 positive regulation of hydrolase activity (GO:0051345) 659 177 111.23 + 1.59 7.96E-08 1.75E-05 protein phosphorylation (GO:0006468) 820 220 138.41 + 1.59 1.66E-09 5.65E-07 taxis (GO:0042330) 388 104 65.49 + 1.59 5.07E-05 4.02E-03 skeletal system development (GO:0001501) 379 101 63.97 + 1.58 7.29E-05 5.33E-03 regulation of neuron projection development (GO:0010975) 428 114 72.24 + 1.58 2.30E-05 2.03E-03 neuron projection development (GO:0031175) 537 143 90.64 + 1.58 2.07E-06 2.62E-04 blood vessel morphogenesis (GO:0048514) 342 91 57.73 + 1.58 1.75E-04 1.07E-02 brain development (GO:0007420) 569 151 96.04 + 1.57 1.31E-06 1.81E-04 cell migration (GO:0016477) 656 174 110.73 + 1.57 2.20E-07 4.12E-05 central nervous system development (GO:0007417) 736 195 124.23 + 1.57 3.23E-08 7.94E-06 sensory system development (GO:0048880) 268 71 45.24 + 1.57 1.01E-03 4.52E-02 plasma membrane bounded cell projection organization (GO:0120036) 926 245 156.30 + 1.57 5.02E-10 1.93E-07 mitotic cell cycle (GO:0000278) 659 174 111.23 + 1.56 2.35E-07 4.30E-05 positive regulation of cell migration (GO:0030335) 402 106 67.85 + 1.56 6.73E-05 5.00E-03 regulation of cell morphogenesis (GO:0022604) 425 111 71.73 + 1.55 6.16E-05 4.69E-03 cell morphogenesis involved in differentiation (GO:0000904) 437 114 73.76 + 1.55 5.84E-05 4.52E-03 negative regulation of organelle organization (GO:0010639) 338 88 57.05 + 1.54 4.59E-04 2.32E-02 regulation of cytoskeleton organization (GO:0051493) 477 124 80.51 + 1.54 2.62E-05 2.29E-03 head development (GO:0060322) 605 157 102.12 + 1.54 2.52E-06 3.14E-04 endocytosis (GO:0006897) 437 113 73.76 + 1.53 7.60E-05 5.40E-03 cell projection organization (GO:0030030) 964 249 162.71 + 1.53 2.74E-09 8.73E-07 movement of cell or subcellular component (GO:0006928) 1122 289 189.38 + 1.53 1.38E-10 6.10E-08 regulation of plasma membrane bounded cell projection organization (GO:0120035) 575 148 97.05 + 1.52 6.84E-06 7.32E-04 transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 416 107 70.22 + 1.52 1.44E-04 9.16E-03 generation of neurons (GO:0048699) 1210 311 204.23 + 1.52 2.74E-11 1.52E-08 positive regulation of cellular component movement (GO:0051272) 428 110 72.24 + 1.52 1.37E-04 8.78E-03 positive regulation of cell cycle (GO:0045787) 339 87 57.22 + 1.52 7.73E-04 3.60E-02 localization of cell (GO:0051674) 737 189 124.40 + 1.52 4.19E-07 7.31E-05 cell motility (GO:0048870) 737 189 124.40 + 1.52 4.19E-07 7.22E-05 neuron development (GO:0048666) 645 165 108.87 + 1.52 2.96E-06 3.61E-04 cell cycle process (GO:0022402) 884 226 149.21 + 1.51 3.18E-08 7.94E-06 locomotion (GO:0040011) 931 238 157.14 + 1.51 1.20E-08 3.21E-06 sensory organ development (GO:0007423) 392 100 66.16 + 1.51 3.30E-04 1.78E-02 positive regulation of cell motility (GO:2000147) 416 106 70.22 + 1.51 2.34E-04 1.32E-02 regulation of cell projection organization (GO:0031344) 581 148 98.07 + 1.51 1.22E-05 1.19E-03 cell morphogenesis (GO:0000902) 555 141 93.68 + 1.51 2.13E-05 1.94E-03 embryo development (GO:0009790) 737 187 124.40 + 1.50 8.70E-07 1.34E-04 neurogenesis (GO:0022008) 1290 326 217.74 + 1.50 4.43E-11 2.37E-08 enzyme linked receptor protein signaling pathway (GO:0007167) 574 145 96.88 + 1.50 2.24E-05 1.99E-03 negative regulation of protein phosphorylation (GO:0001933) 349 88 58.91 + 1.49 1.15E-03 4.89E-02 negative regulation of phosphate metabolic process (GO:0045936) 484 122 81.69 + 1.49 9.98E-05 6.80E-03 neuron differentiation (GO:0030182) 767 193 129.46 + 1.49 8.55E-07 1.33E-04 negative regulation of phosphorus metabolic process (GO:0010563) 485 122 81.86 + 1.49 1.27E-04 8.31E-03 anatomical structure morphogenesis (GO:0009653) 1633 410 275.63 + 1.49 1.57E-13 2.62E-10 regulation of anatomical structure morphogenesis (GO:0022603) 838 210 141.44 + 1.48 3.61E-07 6.44E-05 positive regulation of catalytic activity (GO:0043085) 1192 297 201.20 + 1.48 1.34E-09 4.79E-07 chordate embryonic development (GO:0043009) 482 120 81.36 + 1.48 1.93E-04 1.14E-02 negative regulation of developmental process (GO:0051093) 732 182 123.55 + 1.47 3.36E-06 4.03E-04 intracellular signal transduction (GO:0035556) 1389 345 234.45 + 1.47 6.72E-11 3.15E-08 positive regulation of locomotion (GO:0040017) 443 110 74.77 + 1.47 3.56E-04 1.90E-02 regulation of mitotic cell cycle (GO:0007346) 544 135 91.82 + 1.47 7.49E-05 5.37E-03 embryo development ending in birth or egg hatching (GO:0009792) 497 123 83.89 + 1.47 1.90E-04 1.14E-02 cellular component morphogenesis (GO:0032989) 632 155 106.67 + 1.45 3.97E-05 3.27E-03 positive regulation of kinase activity (GO:0033674) 465 114 78.49 + 1.45 4.71E-04 2.36E-02 hemopoiesis (GO:0030097) 441 108 74.44 + 1.45 6.71E-04 3.19E-02 positive regulation of cell differentiation (GO:0045597) 766 187 129.29 + 1.45 6.54E-06 7.16E-04 regulation of hydrolase activity (GO:0051336) 1062 259 179.25 + 1.44 9.25E-08 1.98E-05 hematopoietic or lymphoid organ development (GO:0048534) 480 117 81.02 + 1.44 4.60E-04 2.31E-02 positive regulation of protein kinase activity (GO:0045860) 427 104 72.07 + 1.44 1.08E-03 4.69E-02 negative regulation of cellular component organization (GO:0051129) 620 151 104.65 + 1.44 6.58E-05 4.93E-03 negative regulation of protein modification process (GO:0031400) 511 124 86.25 + 1.44 3.53E-04 1.89E-02 positive regulation of molecular function (GO:0044093) 1480 359 249.81 + 1.44 3.26E-10 1.28E-07 nervous system development (GO:0007399) 1853 449 312.76 + 1.44 9.75E-13 9.75E-10 regulation of multicellular organismal development (GO:2000026) 1578 381 266.35 + 1.43 1.36E-10 6.18E-08 import into cell (GO:0098657) 514 124 86.76 + 1.43 4.52E-04 2.29E-02 anatomical structure formation involved in morphogenesis (GO:0048646) 691 166 116.63 + 1.42 5.25E-05 4.12E-03 regulation of developmental process (GO:0050793) 2022 485 341.29 + 1.42 3.38E-13 4.22E-10 regulation of cell differentiation (GO:0045595) 1391 333 234.78 + 1.42 4.91E-09 1.50E-06 regulation of cell adhesion (GO:0030155) 535 128 90.30 + 1.42 4.68E-04 2.34E-02 cell cycle (GO:0007049) 1218 291 205.58 + 1.42 7.82E-08 1.75E-05 epithelium development (GO:0060429) 718 171 121.19 + 1.41 5.77E-05 4.48E-03 regulation of organelle organization (GO:0033043) 1144 272 193.09 + 1.41 2.86E-07 5.17E-05 positive regulation of transferase activity (GO:0051347) 535 127 90.30 + 1.41 7.01E-04 3.32E-02 positive regulation of developmental process (GO:0051094) 1063 252 179.42 + 1.40 1.17E-06 1.63E-04 cell development (GO:0048468) 1255 297 211.83 + 1.40 1.14E-07 2.35E-05 regulation of kinase activity (GO:0043549) 725 171 122.37 + 1.40 9.25E-05 6.36E-03 regulation of intracellular signal transduction (GO:1902531) 1540 361 259.93 + 1.39 7.74E-09 2.23E-06 positive regulation of protein phosphorylation (GO:0001934) 778 182 131.32 + 1.39 7.21E-05 5.30E-03 positive regulation of transcription by RNA polymerase II (GO:0045944) 949 222 160.18 + 1.39 1.11E-05 1.10E-03 positive regulation of phosphorylation (GO:0042327) 821 192 138.58 + 1.39 4.95E-05 3.95E-03 positive regulation of phosphorus metabolic process (GO:0010562) 874 204 147.52 + 1.38 3.11E-05 2.65E-03 positive regulation of phosphate metabolic process (GO:0045937) 874 204 147.52 + 1.38 3.11E-05 2.63E-03 regulation of protein kinase activity (GO:0045859) 657 153 110.89 + 1.38 4.04E-04 2.09E-02 regulation of protein phosphorylation (GO:0001932) 1147 267 193.60 + 1.38 1.76E-06 2.27E-04 regulation of cell cycle (GO:0051726) 1020 237 172.16 + 1.38 8.16E-06 8.50E-04 regulation of cellular component organization (GO:0051128) 2183 505 368.46 + 1.37 1.59E-11 9.96E-09 regulation of phosphorus metabolic process (GO:0051174) 1419 328 239.51 + 1.37 1.60E-07 3.19E-05 regulation of phosphate metabolic process (GO:0019220) 1417 327 239.17 + 1.37 1.90E-07 3.65E-05 phosphorylation (GO:0016310) 1116 257 188.37 + 1.36 6.08E-06 6.75E-04 positive regulation of transcription, DNA-templated (GO:0045893) 1234 284 208.28 + 1.36 1.76E-06 2.29E-04 regulation of transferase activity (GO:0051338) 827 190 139.59 + 1.36 1.34E-04 8.67E-03 regulation of signal transduction (GO:0009966) 2561 585 432.27 + 1.35 1.44E-12 1.27E-09 regulation of phosphorylation (GO:0042325) 1248 285 210.65 + 1.35 2.85E-06 3.51E-04 positive regulation of cellular component organization (GO:0051130) 1057 241 178.41 + 1.35 1.97E-05 1.81E-03 animal organ development (GO:0048513) 2300 524 388.21 + 1.35 4.90E-11 2.53E-08 regulation of cellular component biogenesis (GO:0044087) 839 191 141.61 + 1.35 1.78E-04 1.08E-02 regulation of catalytic activity (GO:0050790) 1923 436 324.58 + 1.34 5.78E-09 1.70E-06 regulation of cell communication (GO:0010646) 2841 644 479.53 + 1.34 2.10E-13 3.15E-10 tissue development (GO:0009888) 1205 273 203.39 + 1.34 8.58E-06 8.82E-04 regulation of multicellular organismal process (GO:0051239) 2364 535 399.02 + 1.34 6.51E-11 3.15E-08 system development (GO:0048731) 3318 749 560.04 + 1.34 1.20E-15 1.80E-11 regulation of protein modification process (GO:0031399) 1503 339 253.69 + 1.34 7.73E-07 1.25E-04 regulation of signaling (GO:0023051) 2874 648 485.10 + 1.34 3.92E-13 4.52E-10 positive regulation of protein modification process (GO:0031401) 976 220 164.74 + 1.34 8.83E-05 6.13E-03 positive regulation of nucleic acid-templated transcription (GO:1903508) 1314 295 221.79 + 1.33 6.64E-06 7.21E-04 positive regulation of RNA biosynthetic process (GO:1902680) 1315 295 221.96 + 1.33 6.69E-06 7.21E-04 cell differentiation (GO:0030154) 2706 607 456.74 + 1.33 7.20E-12 5.14E-09 cellular developmental process (GO:0048869) 2782 621 469.57 + 1.32 8.07E-12 5.50E-09 negative regulation of signal transduction (GO:0009968) 1030 229 173.85 + 1.32 1.51E-04 9.55E-03 positive regulation of RNA metabolic process (GO:0051254) 1391 306 234.78 + 1.30 1.80E-05 1.67E-03 regulation of localization (GO:0032879) 2139 470 361.04 + 1.30 4.75E-08 1.15E-05 positive regulation of multicellular organismal process (GO:0051240) 1311 287 221.28 + 1.30 4.71E-05 3.84E-03 multicellular organism development (GO:0007275) 3757 822 634.14 + 1.30 1.87E-14 4.67E-11 positive regulation of gene expression (GO:0010628) 1595 347 269.22 + 1.29 1.01E-05 1.02E-03 negative regulation of cell communication (GO:0010648) 1101 238 185.84 + 1.28 4.33E-04 2.22E-02 regulation of cell proliferation (GO:0042127) 1240 268 209.30 + 1.28 1.74E-04 1.07E-02 negative regulation of nucleic acid-templated transcription (GO:1903507) 1019 220 172.00 + 1.28 7.96E-04 3.67E-02 anatomical structure development (GO:0048856) 4039 871 681.74 + 1.28 4.03E-14 8.63E-11 negative regulation of signaling (GO:0023057) 1104 238 186.34 + 1.28 5.10E-04 2.53E-02 negative regulation of transcription, DNA-templated (GO:0045892) 979 211 165.24 + 1.28 1.17E-03 4.93E-02 negative regulation of RNA biosynthetic process (GO:1902679) 1021 220 172.33 + 1.28 9.31E-04 4.18E-02 signal transduction (GO:0007165) 3413 735 576.07 + 1.28 1.98E-11 1.19E-08 regulation of molecular function (GO:0065009) 2596 559 438.17 + 1.28 1.70E-08 4.39E-06 developmental process (GO:0032502) 4313 928 727.98 + 1.27 3.98E-15 1.49E-11 signaling (GO:0023052) 3650 783 616.08 + 1.27 5.18E-12 3.88E-09 regulation of response to stimulus (GO:0048583) 3256 698 549.57 + 1.27 2.01E-10 8.60E-08 positive regulation of macromolecule biosynthetic process (GO:0010557) 1525 326 257.40 + 1.27 6.76E-05 5.00E-03 cell communication (GO:0007154) 3741 798 631.44 + 1.26 8.94E-12 5.83E-09 positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 1556 331 262.63 + 1.26 7.81E-05 5.52E-03 positive regulation of signal transduction (GO:0009967) 1271 270 214.53 + 1.26 4.21E-04 2.18E-02 negative regulation of response to stimulus (GO:0048585) 1309 277 220.94 + 1.25 4.35E-04 2.22E-02 negative regulation of macromolecule biosynthetic process (GO:0010558) 1220 258 205.92 + 1.25 7.70E-04 3.60E-02 positive regulation of cellular biosynthetic process (GO:0031328) 1595 334 269.22 + 1.24 2.11E-04 1.23E-02 negative regulation of biosynthetic process (GO:0009890) 1292 270 218.07 + 1.24 1.04E-03 4.58E-02 positive regulation of cell communication (GO:0010647) 1385 289 233.77 + 1.24 7.74E-04 3.59E-02 positive regulation of biosynthetic process (GO:0009891) 1620 338 273.44 + 1.24 2.32E-04 1.32E-02 phosphorus metabolic process (GO:0006793) 1907 397 321.88 + 1.23 6.29E-05 4.74E-03 multicellular organismal process (GO:0032501) 4793 997 809.00 + 1.23 5.79E-13 6.20E-10 phosphate-containing compound metabolic process (GO:0006796) 1880 391 317.32 + 1.23 8.44E-05 5.91E-03 cell surface receptor signaling pathway (GO:0007166) 1744 362 294.37 + 1.23 1.91E-04 1.14E-02 positive regulation of signaling (GO:0023056) 1393 289 235.12 + 1.23 1.03E-03 4.55E-02 positive regulation of macromolecule metabolic process (GO:0010604) 2705 558 456.57 + 1.22 2.83E-06 3.50E-04 positive regulation of nitrogen compound metabolic process (GO:0051173) 2584 531 436.15 + 1.22 8.18E-06 8.46E-04 positive regulation of cellular process (GO:0048522) 4248 870 717.01 + 1.21 1.28E-09 4.67E-07 positive regulation of cellular metabolic process (GO:0031325) 2681 548 452.52 + 1.21 9.63E-06 9.82E-04 negative regulation of nitrogen compound metabolic process (GO:0051172) 1941 396 327.62 + 1.21 2.84E-04 1.57E-02 positive regulation of biological process (GO:0048518) 4741 965 800.22 + 1.21 2.27E-10 9.21E-08 positive regulation of metabolic process (GO:0009893) 2918 593 492.52 + 1.20 6.03E-06 6.74E-04 negative regulation of cellular metabolic process (GO:0031324) 2082 421 351.42 + 1.20 3.34E-04 1.80E-02 organelle organization (GO:0006996) 2964 597 500.29 + 1.19 1.42E-05 1.36E-03 negative regulation of cellular process (GO:0048523) 3791 761 639.88 + 1.19 6.36E-07 1.06E-04 regulation of transcription by RNA polymerase II (GO:0006357) 2163 433 365.09 + 1.19 5.76E-04 2.81E-02 cellular protein modification process (GO:0006464) 2661 531 449.15 + 1.18 1.27E-04 8.37E-03 protein modification process (GO:0036211) 2661 531 449.15 + 1.18 1.27E-04 8.34E-03 cellular component organization (GO:0016043) 4719 935 796.51 + 1.17 8.83E-08 1.92E-05 cellular response to stimulus (GO:0051716) 4737 928 799.55 + 1.16 7.14E-07 1.18E-04 negative regulation of biological process (GO:0048519) 4260 833 719.04 + 1.16 5.49E-06 6.29E-04 macromolecule modification (GO:0043412) 2841 555 479.53 + 1.16 5.74E-04 2.81E-02 regulation of cellular process (GO:0050794) 8281 1613 1397.73 + 1.15 3.39E-15 1.69E-11 cellular component organization or biogenesis (GO:0071840) 4892 951 825.71 + 1.15 1.56E-06 2.09E-04 regulation of transcription, DNA-templated (GO:0006355) 2840 552 479.36 + 1.15 8.52E-04 3.86E-02 regulation of nucleic acid-templated transcription (GO:1903506) 2888 559 487.46 + 1.15 1.11E-03 4.76E-02 regulation of biological process (GO:0050789) 8845 1684 1492.93 + 1.13 1.58E-12 1.32E-09 biological regulation (GO:0065007) 9384 1780 1583.91 + 1.12 1.42E-13 2.66E-10 regulation of nitrogen compound metabolic process (GO:0051171) 4786 904 807.82 + 1.12 2.01E-04 1.18E-02 regulation of cellular metabolic process (GO:0031323) 5042 949 851.03 + 1.12 1.87E-04 1.12E-02 regulation of primary metabolic process (GO:0080090) 4932 924 832.46 + 1.11 4.50E-04 2.29E-02 regulation of macromolecule metabolic process (GO:0060255) 5020 940 847.32 + 1.11 4.03E-04 2.10E-02 response to stimulus (GO:0050896) 5945 1097 1003.45 + 1.09 5.50E-04 2.71E-02 cellular aromatic compound metabolic process (GO:0006725) 2835 403 478.51 - .84 3.30E-04 1.79E-02 heterocycle metabolic process (GO:0046483) 2810 398 474.29 - .84 2.54E-04 1.43E-02 nucleobase-containing compound metabolic process (GO:0006139) 2679 379 452.18 - .84 3.72E-04 1.95E-02 organic cyclic compound metabolic process (GO:1901360) 2998 423 506.03 - .84 1.10E-04 7.41E-03 nucleic acid metabolic process (GO:0090304) 2111 294 356.31 - .83 7.61E-04 3.57E-02 cellular nitrogen compound metabolic process (GO:0034641) 3213 442 542.32 - .82 4.45E-06 5.26E-04 RNA metabolic process (GO:0016070) 1526 204 257.57 - .79 8.16E-04 3.75E-02 cellular nitrogen compound biosynthetic process (GO:0044271) 1521 199 256.73 - .78 3.06E-04 1.67E-02 gene expression (GO:0010467) 1825 230 308.04 - .75 5.60E-06 6.36E-04 oxidation-reduction process (GO:0055114) 788 90 133.01 - .68 2.15E-04 1.25E-02 cellular amide metabolic process (GO:0043603) 705 76 119.00 - .64 7.34E-05 5.31E-03 aromatic compound catabolic process (GO:0019439) 425 44 71.73 - .61 1.08E-03 4.68E-02 RNA processing (GO:0006396) 798 80 134.69 - .59 1.64E-06 2.16E-04 nucleobase-containing compound catabolic process (GO:0034655) 380 35 64.14 - .55 2.26E-04 1.29E-02 ribonucleoprotein complex biogenesis (GO:0022613) 425 39 71.73 - .54 9.61E-05 6.58E-03 drug metabolic process (GO:0017144) 513 47 86.59 - .54 1.33E-05 1.28E-03 mRNA processing (GO:0006397) 435 36 73.42 - .49 5.69E-06 6.41E-04 peptide metabolic process (GO:0006518) 499 41 84.23 - .49 1.06E-06 1.56E-04 amide biosynthetic process (GO:0043604) 489 40 82.54 - .48 1.15E-06 1.63E-04 mRNA metabolic process (GO:0016071) 643 52 108.53 - .48 1.17E-08 3.20E-06 ribosome biogenesis (GO:0042254) 275 22 46.42 - .47 2.32E-04 1.32E-02 generation of precursor metabolites and energy (GO:0006091) 345 25 58.23 - .43 4.51E-06 5.24E-04 RNA splicing (GO:0008380) 372 25 62.79 - .40 4.90E-07 8.35E-05 ribonucleoside triphosphate metabolic process (GO:0009199) 201 13 33.93 - .38 1.76E-04 1.08E-02 translation (GO:0006412) 375 24 63.30 - .38 1.15E-07 2.33E-05 purine ribonucleoside triphosphate metabolic process (GO:0009205) 195 12 32.91 - .36 1.35E-04 8.69E-03 peptide biosynthetic process (GO:0043043) 393 24 66.33 - .36 1.92E-08 4.87E-06 purine nucleoside triphosphate metabolic process (GO:0009144) 202 12 34.10 - .35 7.52E-05 5.37E-03 nucleoside triphosphate metabolic process (GO:0009141) 221 13 37.30 - .35 2.14E-05 1.93E-03 mRNA splicing, via spliceosome (GO:0000398) 279 16 47.09 - .34 1.00E-06 1.50E-04 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) 279 16 47.09 - .34 1.00E-06 1.49E-04 RNA splicing, via transesterification reactions (GO:0000375) 282 16 47.60 - .34 7.34E-07 1.20E-04 RNA 3'-end processing (GO:0031123) 116 6 19.58 - .31 1.14E-03 4.87E-02 mitochondrial gene expression (GO:0140053) 136 7 22.96 - .30 4.51E-04 2.29E-02 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) 119 6 20.09 - .30 8.19E-04 3.75E-02 proton transmembrane transport (GO:1902600) 123 6 20.76 - .29 5.91E-04 2.86E-02 ATP metabolic process (GO:0046034) 165 8 27.85 - .29 4.74E-05 3.84E-03 translational initiation (GO:0006413) 145 7 24.47 - .29 1.69E-04 1.05E-02 mitochondrial translation (GO:0032543) 111 5 18.74 - .27 7.77E-04 3.60E-02 translational elongation (GO:0006414) 124 5 20.93 - .24 1.37E-04 8.76E-03 protein localization to endoplasmic reticulum (GO:0070972) 134 5 22.62 - .22 4.78E-05 3.85E-03 mitochondrial translational elongation (GO:0070125) 88 2 14.85 - .13 2.17E-04 1.25E-02 protein targeting to ER (GO:0045047) 108 2 18.23 - .11 1.43E-05 1.36E-03 establishment of protein localization to endoplasmic reticulum (GO:0072599) 112 2 18.90 - .11 6.16E-06 6.79E-04 ATP biosynthetic process (GO:0006754) 64 1 10.80 - .09 1.06E-03 4.63E-02 mitochondrial translational termination (GO:0070126) 89 1 15.02 - .07 2.73E-05 2.36E-03 translational termination (GO:0006415) 95 1 16.03 - .06 1.24E-05 1.20E-03 SRP-dependent cotranslational protein targeting to membrane (GO:0006614) 96 1 16.20 - .06 7.60E-06 8.02E-04 cotranslational protein targeting to membrane (GO:0006613) 100 1 16.88 - .06 5.27E-06 6.08E-04